For example, miR-29c, the miR-34 family, miR-143, miR-145 and miR-9 are downregulated in NPC, leading to increased expression of their target genes which influence the function and synthesis of extracellular matrix proteins, which in turn affects tumor invasion and metastasis, and activates the TGF-Wnt, IP3 and VEGF signaling pathways [44, 45]. This evidence concerns the gene VEGFA and nasopharyngeal carcinoma.