FOXO3 and colorectal carcinoma: And the western blotting analysis of CRC cell lines (cetuximab sensitive: Caco2; cetuximab resistant: HT29, Colo205) showed that expression of FoxO3a was lower in Caco2 compared with HT29 and colo205 cells suggest that FoxO3a might associated with cetuximab resistance (Figure 1C).