Several anticancer drugs, including 5-Fu, camptothecin, cisplatin, docetaxel, etoposide, mitoxantrone, doxorubicin, and Oxaliplatin among others, can induce autophagy; however, only a fraction of drugs, such as mitoxantrone, doxorubicin and Oxaliplatin, can promote CRT translocation from the ER lumen to the surface of stressed and dying cancer cells, inducing bona fide ICD [1]. This evidence concerns the gene CALR and cancer.