ATG12 and ovarian cancer: In another ovarian cancer cell, studies convincingly illustrated that ghrelin, emodin and B19, which was a novel monocarbonyl analogue of curcumin, played an antitumor effect of on HO-8910 cells by inducing autophagy, including increased level of MAP LC3, Beclin1, Atg12-Atg5 complex, promotion of transformation of LC3-I to LC3-II and decreased level of p62 [83–85].