Kong and colleagues showed that wild-type p53 sensitized multidrug resistant (MDR) human ovarian carcinoma cell lines to vincristine, cisplatin, pirarubicin and etoposide by inducing apoptosis and decreasing autophagy, while mutant p53 reversed the MDR by trigging autophagic cell death, necrosis and apoptosis [64]. Here, TP53 is linked to ovarian carcinoma.