Of special note is that, Mono-Pt, which is a novel monofunctional platinum (II) complex, played an anticancer effect in ovarian cancer via increasing the punctate distribution of LC3 and the ratio of LC3-II to LC3-I, Mono-Pt-induced cell death was significantly restricted by the knockdown of either Beclin1, ATG7 or the autophagy inhibitors 3-methyladenine, chloroquine and bafilomycin A1. This evidence concerns the gene MAP1LC3A and ovarian cancer.