It was suggested that autophagy had a protective mechanisms in the regulation of chemosensitivity to cisplatin with virtually promotion of autophagy contributed to cisplatin resistance in human ovarian cancer, inhibition of autophagy through using autophagy inhibitor and Beclin1 small interfering RNA (SiRNA) increased cisplatin-induced cell death and apoptosis [49, 50]. This evidence concerns the gene BECN1 and ovarian cancer.