For example, the causal variants of nondiabetic end-stage renal disease in APOL1 gene are common in AAs but absent in European Americans [65]; the cardiomyopathy causal variant at MYBPC3 is common in individuals from South Asia but not observed elsewhere [66]; and the ABCA1 variant that reduces cholesterol efflux is Native-American ancestry specific [67]. This evidence concerns the gene ABCA1 and stage 5 chronic kidney disease.