NTRK1 and cancer: To investigate the signaling network which might involve in miR-31-mediated DDP-resistance in GBC cells, we looked into the potential binding sites of miR-31 by the online miRNA target gene prediction tool (Target Scan and miRBase databases, Supplementary Table S1), and identified Src, a non-receptor tyrosine kinase known to regulate the drug-susceptibility of cancer cells, as our candidate (Figure 3A).