HK2 and metastatic malignant neoplasm in the lymph nodes: The overexpression of HK2 was positively correlated with tumor stage, differentiation and lymph node metastasis, as well as with a reduction in survival [10, 16, 21, 32].To the best of our knowledge, the present study is the first meta-analysis systematically exploring the prognostic value of elevated HK2 expression in solid tumor.