There was no association between the miR-146a polymorphism and NUMB expression in the CRC cell lines (Fig 3B), however, immunoblotting analysis revealed that NUMB expression of CRC cell lines with pre-miR-146a/C (CaR1, Lovo and DLD-1) was lower than WiDr and HT29, CRC cell lines without pre-miR-146a/C (Fig 3C). The gene discussed is NUMB; the disease is colorectal carcinoma.