SIRT6 and neoplasm: Since naturally occurring tumor-associated mutations in SIRT6 were shown to alter its stability, localization, and/or enzymatic activity[19], we checked SIRT6 status in HCC tissues and cell lines using several public databases such as COSMIC (Catalogue of Somatic Mutations in Cancer, http://cancer.sanger.ac.uk/cosmic) and Cancer Genome Atlas (https://tcga-data.nci.nih.gov/docs/publications/tcga/).