FBN1 and thoracic aortic aneurysm: Marfan syndrome (MFS) is an autosomal-dominant disorder of connective tissue caused by mutations in the fibrillin-1 gene (FBN1) located on chromosome 15q15-31 with an estimated prevalence of 1 in 3,000–5,000 [1] leading to multi-systemic clinical problems in the skeletal, ocular and cardiovascular systems; however, sudden death is most often due to thoracic aortic aneurysms leading to aortic dissection and rupture [2, 3].