AKR1C3 and neoplasm: AKR1B10, AKR1C1, AKR1C2 and AKR1C3 constitute some of the most inducible targets of NRF2 in human systems, both normal and tumour-derived (Lou et al, 2006; MacLeod et al, 2009; Agyeman et al, 2012; Jung et al, 2013).