Remarkably, Taqman analysis of RNA indicated that SFN and TBE-31 induced AKR1B10, AKR1C1/2 and AKR1C3 mRNA in almost all tumour cell lines with wild-type KEAP1 and NRF2, independent of the tissue or origin (Figure 2, fold change values are provided in Supplementary Table 2). This evidence concerns the gene AKR1C1 and neoplasm.