Thus, in liver injury, the exosome-mediated activation of TLR3 in HSCs exacerbates liver fibrosis by enhancing IL-17A production by γδ T cells, which might be associated with HSC stimulation by unknown self-TLR3 ligands from damaged hepatocytes.39 Chemokine receptor 6 (CCR6) and chemokine ligand (CCL) 20 expression were intrahepatically upregulated in patients with chronic liver diseases compared to control liver, with periportal accumulation of CCR6(+) mononuclear cells and CCL20 induction by hepatic parenchymal cells. This evidence concerns the gene CCR6 and Hepatic fibrosis.