This combined analysis pointed to Ankyrin-3 (Ank3), a genetic risk factor for bipolar disorder and schizophrenia 25, 26, 27 that plays a pivotal role as scaffolding protein in specific membrane domains, such as the node of Ranvier and the axon initial segment.28, 29, 30 Moreover, a role for ankyrin-G (ANKG) protein in regulating the post-synaptic compartment organization and function has recently emerged,31, 32 suggesting its potential for mediating the effects of stress exposure on dysfunctions associated with several psychiatric conditions.33, 34, 35, 36. Here, ANK3 is linked to schizophrenia.