ANK3 and stress-related disorder: Moreover, given the possibility that Ank3 expression can be modulated by pharmacological intervention 31 and that the behavioral phenotype induced by Ank3 suppression in the mouse brain may be reverted by chronic lithium administration,83 we believe that Ank3 may represent a novel molecular marker as well as a target for drug intervention in stress-related disorders with a neurodevelopmental origin.