Finally, we demonstrated, in healthy adult subjects, that variation in the Ank3 gene affecting gene expression interacted with an early stress factor (obstetric complications), in modulating prefrontostriatal connectivity and behavioral correlates of working memory, a cognitive phenotype tightly linked with different psychiatric disorders.37 Overall, our results suggest that alterations of Ank3 expression may contribute to the effects of perinatal stress on the vulnerability to psychiatric conditions. Here, ANK3 is linked to psychiatric disorder.