ANK3 and bipolar disorder: This combined analysis pointed to Ankyrin-3 (Ank3), a genetic risk factor for bipolar disorder and schizophrenia 25, 26, 27 that plays a pivotal role as scaffolding protein in specific membrane domains, such as the node of Ranvier and the axon initial segment.28, 29, 30 Moreover, a role for ankyrin-G (ANKG) protein in regulating the post-synaptic compartment organization and function has recently emerged,31, 32 suggesting its potential for mediating the effects of stress exposure on dysfunctions associated with several psychiatric conditions.33, 34, 35, 36