Furthermore, the latest mega-analysis of the Psychiatric Genetic Consortium demonstrated that SNPs in high LD (based on the CEU population data) with rs1106634, namely rs6586899 (r2=0.96) and rs4335136 (r2=0.86), showed nominally significant associations with major depressive disorder (rs6586899 P=0.004, rs4335136 P=0.017), while the functional rs1042426 has a trend effect (P=0.089) supporting the weak but replicable role of ATP6V1B2 in lifetime depression.46 The gene discussed is ATP6V1B2; the disease is major depressive disorder.