Consistent with these data, decreased expression of VGLUT1 was reported in layer V of both MDD and BD samples from the dorsolateral PFC (BA9).209 A reduction in VGLUT1/2 mRNA may be due to structural loss of presynaptic terminals or alternatively a functional decrease in glutamate release while conversely, increased VGLUT expression may be indicative of greater numbers of glutamate neurons and/or greater presynaptic innervation and glutamate neurotransmission.198, 206. The gene discussed is SLC17A7; the disease is major depressive disorder.