SLC17A7 and major depressive disorder: Eastwood and Harrison reported increased VGLUT1 expression in the supragenual ACC (BA24) in BD, a result they hypothesize is indicative of abnormally increased glutamate neurotransmission, rather than, or in addition to, alterations in glutamate metabolism or cycling.208 Consistent with these data, Gray et al.198 reported increased VGLUT1 expression in the dorsolateral PFC of female MDD samples using quantitative PCR.