Using eight markers of inflammation (Serpin Family A Member 3, IL-1, IL-1R1, IL-6, IL-8, IL-18, TNF and Prostaglandin-Endoperoxide Synthase 2), the authors were able to cluster the samples into a high inflammation subgroup consisting of 16 samples with schizophrenia (46%), 10 samples with BD (29%) and 9 controls (26%), and a low inflammation subgroup consisting of 19 samples with BD, 20 samples with schizophrenia and 25 controls. This evidence concerns the gene TNF and schizophrenia.