A more extensive follow-up study by these authors showed a greater than three-fold increase in transmembrane TNF expression in ACC (BA24) samples from BD patients, as well as a 51 and 67% decrease in TNFR2 expression in BA46 samples from MDD and BD subjects, respectively.107 These results suggest illness-specific regional disruptions in TNF signaling. This evidence concerns the gene TNF and Behcet disease.