We used a high cholesterol (HC-) diet as previously described by Hartvigsen and colleagues,10 to induce hypercholesterolemia in Ldlr-/- mice, closely reflecting the lipid profile of an FH patient without inducing other concomitant metabolic disorders, such as hypertriglyceridaemia, which may independently drive atherosclerosis. The gene discussed is LDLR; the disease is atherosclerosis.