In vivo treatment with NR2B receptor antagonists reproduce some features of schizophrenia-like behavior, such as hyperlocomotion and impaired PPI in rodents42, 43, 44, 45, just like the cortical genetic deletion of NR2B in mice46, pointing to the determinant role of this subunit of NMDA receptor in shaping of the schizophrenia-like behavioral changes. Here, GRIN2B is linked to schizophrenia.