Pathway and network analyses of deregulated genes in CEM/ADR5000 cells revealed connections to drug resistance and carcinogenesis, e.g. “cell death of leukaemia” and “apoptosis” pathways were inhibited, whereas the “transport of cyclosporine” network was predicted to be activated due to up-regulated ABCB1. The networks involving ABCB1 and ABCG2 are summarised in Fig. 1. This evidence concerns the gene ABCG2 and leukemia.