LRBA and inflammatory bowel disease: Consistent with this, several recently identified individuals with homozygous or compound heterozygous mutations in LRBA that result in LRBA protein deficiency suffer from immune dysregulation and manifest a spectrum of clinical complications including common variable immune deficiency (CVID), recurrent infections and autoimmunity that also includes inflammatory bowel disease (IBD)8, 9, 10, 11.