ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: In our study, after treatment with AKI603, CML cells with BCR-ABL-T315I mutation displayed a serial of senescent morphological and functional changes such as enlarged and flattened morphology, increased levels of p21 protein and enhanced SA-β-gal staining as well as imatinib sensitive CML cells (Fig. 3).