Supplementation with 7,8-DHF during the juvenile and adolescent stages of offspring of prenatal mice exposed to poly(I:C) led to the prevention of behavioral changes (e.g., cognitive deficits and PPI deficits), decreased BDNF-TrkB signaling in PFC and CA1 of hippocampus, and loss of PV and PGC-1α immunoreactivity in the PrL of mPFC and CA1 of hippocampus at adulthood after MIA. This evidence concerns the gene BDNF and Cognitive impairment.