To examine whether BDNF-TrkB signaling plays a role in the cognitive deficits of juvenile offspring of poly(I:C)-treated group, we measured the levels of BDNF, p-TrkB and TrkB in prefrontal cortex (PFC), nucleus accumbens (NAc) and CA1, CA3, dentate gyrus (DG) of hippocampus in the juvenile offspring of two groups. This evidence concerns the gene BDNF and Cognitive impairment.