In this experimental study, human normal liver cells (LO2), rat glioma cells (C6), and human GBM cells were treated with KuA in vitro, the proliferation and cloning efficiency of human GBM cells were inhibited in a time- and dose-dependent manner, Little effect on human normal liver cells (LO2), were observed; human GBM cells are more sensitive to KuA than rat glioma cells (C6). The gene discussed is PEDS1; the disease is glioma.