Consistent with the microarray results, the qRT-PCR analysis revealed that the expression levels of HCN3 (P < 0.05) and linc01105 (P < 0.01) were higher, whereas MEG3 expression was lower (P < 0.01), in neuroblastoma tissue compared to para-tumor tissue (Supplementary Fig. 4). The gene discussed is SILC1; the disease is neoplasm.