To investigate whether GLTSCR2 might play any role in viral replication, we used small interfering RNA (siRNA) to knock down GLTSCR2 in cells, followed by infection with Rhabdoviridae vesicular stomatitis virus (VSV), Paramyxoviridae Newcastle disease virus (NDV), and Coronaviridae infectious bronchitis virus (IBV). The gene discussed is NOP53; the disease is infection.