In limiting PTP1B’s regulation of cortactin phosphorylation at invadopodia, MenaINV may sensitize carcinoma cells to produce mature invadopodia in response to a variety of β1-integrin ligands present in the tumor microenvironment, such as fibronectin and type-1 collagen65, 66, 67. This evidence concerns the gene PTPN1 and neoplasm.