Furthermore, the discovery of MenaINV-dependent invadopodium maturation is consistent with the functional relationship between Mena isoform expression patterns and TMEM intravasation sites found in breast tumors29, 48, 84, two prognostics which are independently predictive of metastatic recurrence and mortality in breast cancer patients29, 46, 47, 49, 50. The gene discussed is EGFR; the disease is breast carcinoma.