The Bogalusa Heart Study which followed their paediatric cohort found that the prevalence of metabolic syndrome in adults was higher in the insulin-resistant obesity group than in the insulin-sensitive obesity group (34.9% vs. 24.3%, p = 0.008) and those with insulin-resistance were 1.7 times (p = 0.011) more likely to have metabolic syndrome in adulthood compared to those who were insulin-sensitive38. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.