When high fasting insulin and insulin resistance were examined as categorical variables, BMI (adjusted OR = 1.48; 95% confidence interval (CI) 1.11–1.98, p-value 0.008) and WC (adjusted OR = 1.10; 95% confidence interval (CI) 1.01–1.20, p-value 0.04) showed significantly increased risk of hyperinsulinaemia in our overweight and obese adolescents. The gene discussed is INS; the disease is Insulin resistance.