PTPN11 and acute lymphoblastic leukemia: Analysis of Ras mutations (NRAS, KRAS, NF1 and PTPN11) across the RNAseq cohort revealed a similar prevalence of Ras mutations as other subtypes of ALL previously reported to be enriched for Ras mutations (for example, hyperdiploid and MLL-rearranged ALL (Supplementary Fig. 7)).