Analysis of Ras mutations (NRAS, KRAS, NF1 and PTPN11) across the RNAseq cohort revealed a similar prevalence of Ras mutations as other subtypes of ALL previously reported to be enriched for Ras mutations (for example, hyperdiploid and MLL-rearranged ALL (Supplementary Fig. 7)). The gene discussed is NF1; the disease is acute lymphoblastic leukemia.