In order to correlate xCT expression and methylation, we determined the SLC7A11 (xCT) methylation status in bladder cancer patients (n = 52) and their matched non-tumor tissues (n = 106) and found significant hypomethylation of SLC7A11 in tumors compared to their matched non-tumor tissues (Figure 3G). Here, SLC7A11 is linked to urinary bladder cancer.