The genetic characterization mutations reported in bladder cancer have contributed to the molecular subtyping of this disease: FGFR3 and TP53 mutations in UroA and UroB cluster [7], FGFR3 mutation in Cluster I [6], FGFR3 and TSC1 mutations in the basal and luminal phenotype [8, 9]. This evidence concerns the gene FGFR3 and urinary bladder carcinoma.