Based on these phase I trial results, the RPIID for nimotuzumab is a 200 mg weekly i.v. and for gefitinib 250 mg daily p.o.[3] We evaluated the efficacy of dual inhibition of the EGFR pathway with nimotuzumab plus gefitinib in advanced NSCLC patients who were previously treated with platinum-based chemotherapy. Here, EGFR is linked to non-small cell lung carcinoma.