Recently, the SQUIRE, FLEX, and INSPIRE trials showed that the combination of EGFR monoclonal antibodies, such as necitumumab and cetuximab, with platinum-based cytotoxic chemotherapy as a first-line therapy in squamous cell lung cancer led to prolonged survival outcomes, while the same results were not seen in adenocarcinoma [8–11]. Here, EGFR is linked to squamous cell lung carcinoma.