KLK3 and Familial prostate cancer: The AUC for the probability of predicting high Gleason score prostate cancer by age, PSA, PSAD, and serum monocyte fraction was 0.841 (95% confidence interval [CI] 0.814-0.865), whereas the AUC by PSA was 0.754 (95% CI 0.722-0.784) in all men.