Age, PSA, PSAD, monocyte fraction, basophil fraction, and MLR were significantly higher (p < 0.05), whereas prostate volume, serum WBC count, and serum neutrophil fraction were significantly lower (p < 0.01) in the men in whom high Gleason score prostate cancer was found than in those with negative biopsy and in those in whom low Gleason score prostate cancer was found. The gene discussed is KLK3; the disease is Familial prostate cancer.