Age, PSA, PSAD, monocyte fraction, and MLR were significantly higher (p < 0.01), CRP was not significantly higher (p = 0.146), and prostate volume was significantly lower (p < 0.01) in the men in whom high Gleason score prostate cancer was found than in those with negative biopsy and in those in whom low Gleason score prostate cancer was found. This evidence concerns the gene KLK3 and Familial prostate cancer.