AGT and ischemia: Contrast to the previous reports that miR-214 was upregulated in the myocardium of a rat AAC model, and of a mouse ischemia/reperfusion (IR) injury model and of a rat isoproterenol injection model [16–19], our present data showed that miR-214-3p was significantly down-regulated in the myocardium of a mouse Ang-II infusion model, and was upregulated in Ang-II-induced mouse myofibroblasts.