IFIT1 and viral infectious disease: In addition, SLE patients are prone to virus infection due to the abnormality in immune response when comparing with healthy counterparts, the vulnerability may induce the expression of IFIT1. Although the mechanism between IFIT1 expression and podocytes damage has not yet been identified, we did observe the inverse association between the IFIT1 expression and some podocytes proteins which are essential to maintain normal function of glomerular filtration.