HK2 and laryngeal carcinoma: Although the exact mechanisms underlying HK-II-mediated radioresistance of laryngeal carcinoma have not been fully elucidated, as a number of factors regulating HK-II expression have already been investigated, we speculate that novel inhibitors targeting the HK-II-mediated Warburg effect may emerge as promising tools to enhance the radiosensitivity of laryngeal carcinoma.