Shimura et al. found that inhibition of the Akt pathway by API-2, an Akt inhibitor, eliminated the aerobic glycolysis enhanced by increased Glut-1 expression in HepG2 (human liver cancer) and HeLa (cervical cancer) cell lines, which exhibits radioresistance acquired by long-term exposure to fractionated radiation. The gene discussed is AKT1; the disease is liver cancer.