POLG and Sensory neuropathy: In a previous study, it has been shown that the number of dorsal root ganglion cells and also posterior horn cells was lower in a patient with pA467T/pX1240Q mutations of the POLG gene as compared to that in control subjects.3 Anterior horn cells were also relatively low in number in this patient, but the difference to the controls did not reach significance.3 Therefore, it can be hypothesized that sensory neuropathy in patients with multiple mtDNA deletions is not only of the axonal type but also might additionally be caused by nerve cell loss.