CCR3 and chronic obstructive pulmonary disease: Some years ago, D'Armiento and colleagues [14] described the association between level in lung lavage of eotaxin-1, a CC chemokine (CCL11) that binds to CC chemokine receptor 3 (CCR3) on the surface of eosinophils thereby inducing eosinophil activation and migration, and rapidly progressive disease in COPD patients with emphysema.