For example, when assessing a TP53 variant, the phenotype is considered strong if the patient meets classic Li-Fraumeni syndrome criteria: a proband with sarcoma diagnosed before 45 years, a first-degree relative with any cancer before 45 years, and a second-degree relative with any cancer before age 45 years or a sarcoma at any age [15]. This evidence concerns the gene TP53 and sarcoma.