Parker-Duffen et al. [11] recently observed that AdipoR2-deficient mice submitted to hindlimb ischemic surgery exhibited severely attenuated revascularization, whereas AdipoR1-deficient mice exposed to an HF diet developed metabolic perturbations characterized by a greater body weight and fat mass, hepatic steatosis, impaired glucose tolerance. Here, ADIPOR2 is linked to hydrops fetalis.