Among others, adult-onset Still's disease (AOSD; Naumann et al., 2010; Nordström et al., 2012), systemic juvenile idiopathic arthritis (SOJA; Hedrich et al., 2012; Ruperto et al., 2012a,b), Behçet's disease (BD; Cantarini et al., 2012a,b, 2015b; Vitale et al., 2014; Emmi et al., 2016) and crystal-induced arthritis (So et al., 2007; Schlesinger et al., 2012) are prime examples of multifactorial AIDs showing a good response to IL-1-INH. This evidence concerns the gene IL1B and adult-onset Still disease.