IL1B and Crouzon syndrome-acanthosis nigricans syndrome: Distinguishing by age, IL-1-INH plus corticosteroids were administered to 46 (41.4%) pediatric patients, corresponding to 62 (45.2%) pediatric treatment courses (46 with ANA and 16 with CAN), and 214 (51.6%) adult patients, corresponding to 223 (57.03%) treatment courses (198 with ANA and 25 with CAN).