Opportunistic infections in adult patients can also be a presentation of autoantibodies that inhibit cytokines including (but not only) anti interferon-gamma (anti IFN-γ) self-antibodies in previously healthy adults presenting with severe Mycobacterial infections  4 or antibodies to interleukin-17 (IL-17) and IL-22 that are associated with chronic candidiasis 5 this group of autoantibodies are now recognized as phenocopies or acquire immune disorders resembling primary genetic immunodeficiency diseases 6. The gene discussed is IFNG; the disease is Opportunistic infection.