CYP11B1 and congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: Since their discovery, several mutations in the CYP11B1 gene that are associated with 11-beta-hydroxylase deficiency have been described, and the vast majority of these mutations have a noticeable demographic or geographical distribution: the mutation p. R448H described in Jewish immigrants from Morocco 5; the mutations g.4671_4672insC and g.2791G>A described in Brazilians 6; the mutations p.Q356X (c.1066C>T, rs146124466) and p.G379V (c.1136G>T) described in Tunisians and persons of African origin 3,7; and more recently, the mutations p.E67fs and p.R448H described in Croatian families 8.