Finally, the effects of TrkB agonist 7,8-dihydroxyflavone (7,8-DHF)35, TrkB antagonist ANA-1236, and selective serotonin reuptake inhibitor (SSRI) fluoxetine in depression-like phenotype of α7 nAChR KO mice were examined. The gene discussed is CHRNA7; the disease is major depressive disorder.