In the medical literature, a large number of studies have been conducted to identify HLA-DRB1 genetic variants (such as DRB1*07, DRB1*12 and DRB1*15) associated with HCC risk and clinical outcomes, but many of the findings in these studies are inconsistent and inconclusive [12, 20, 24–26]. The gene discussed is HLA-DRB1; the disease is hepatocellular carcinoma.