Therefore, the differentially methylated specific genes (NTRK2, MAPKAPK2, CRK, and NFATC2) and the dysregulated miRNAs (mir-148a, mir-374a and mir-494) in the MAPK and ErbB pathways cause cell proliferation, adhesions and migration and the immune cell infiltration to cancer cells during early HCC. Here, MAPKAPK2 is linked to hepatocellular carcinoma.