The differences in epigenetic miRNA regulation and methylation causes a the shift from the MAPK to the TGF-β pathway, leading to the dysregulation of the target genes of TFs, resulting in favorable conditions for the progression of HCC from stage II to stage III (such as cell proliferation, anti-apoptosis, aberrant cell cycle, cell survival, and metastasis). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.