Therefore, the differentially methylated specific genes (NTRK2, MAPKAPK2, CRK, and NFATC2) and the dysregulated miRNAs (mir-148a, mir-374a and mir-494) in the MAPK and ErbB pathways cause cell proliferation, adhesions and migration and the immune cell infiltration to cancer cells during early HCC. This evidence concerns the gene EGFR and hepatocellular carcinoma.