MAP2K4 and hepatocellular carcinoma: Most of miRNA-regulated or methylated genes and miRNAs including AKT1 [59, 60], BMPR1B [61], FOS [62], GDF6 [63], HRAS [59, 62], IL1R1 [63], IL7R [61], JUND [60], MAP2K4 [61], MYC [62, 63], NFATC2 [59], NFKB1 [63], NTRK2 [63], PDGFB [59], PPP3CA [63], PTK2 [62], STAT3 [64], let-7e [65], mir-148a [65], mir-494 [66], mir-182 [65], mir-590 [67], mir-340 [65], and mir-93 [65] in Figure 6 can be supported by large-scale analysis studies of DNA methylation data or gene/miRNA expression data in HCC.