In both tumour cell types, TRAIL-induced apoptosis is regulated by the equilibrium between functional (DR4 and DR5) and decoy receptors (DcR1, DcR2 and OPG), caspase 3, 8, 9 and 10 expression levels and the equilibrium between caspase 8 and its inhibitory analogues cFLIPS and cFLIPL. The gene discussed is TNFSF10; the disease is neoplasm.