The developmental and stress-regulated alternative TrkAIII splice variant of the neurotrophin receptor tropomyosin related kinase A (TrkA) is expressed by advanced stage human neuroblastomas (NB) and NB cell lines, associates with metastatic disease, worse prognosis and post-therapeutic disease-relapse in high TrkA expressing unfavourable tumours and exhibits oncogenic activity in NB models [1–5]. This evidence concerns the gene NTRK1 and metastatic neoplasm.