BCL2 and cancer: The dysregulation of either apoptosis associated genes like Bcl2-family members or of the tumor suppressor p53, controlling Bcl2-family members in a transactivation-dependent (Bax) as well as in transactivation independent (Bcl2, Bcl-xL, Bcl-w, Mcl-1) manner [18–19], may lead to the formation of cancer or treatment resistance [20].