With respect to the p53 state of the ovarian cancer cell lines with different genetic background harboring either wildtype (TOV21G, A2780) or functionally mutated p53 (OVCAR3p53R248Q, TOV112Dp53R175H, A2780-cisp53K351N), or even lacking p53 expression (SKOV3) the strong pro-apoptotic effects observed in the recent study might suggest a potential p53-independent mode of action of miR-1912-5p, -147b-5p, -96-5p and -3073a-3p that offers the opportunity to overcome p53 dependent treatment resistance. The gene discussed is TP53; the disease is ovarian carcinoma.