CD86 and neoplasm: In strong agreement with these results, treatment with RdB/IL12/shVEGF significantly increased the number of CD86+/CD11c+ mature DCs that infiltrated the tumor tissue in comparison with either RdB/shVEGF or RdB/IL12, suggesting that RdB/IL12/shVEGF makes the tumor microenvironment more favorable for recruitment and infiltration of DCs (Figure 5C).