As shown in Supplementary Figure S2, there was no detectable accumulation of both IL-12 and IFN-γ in serum following administration of oncolytic Ads (RdB, RdB/shVEGF, RdB/IL12, or RdB/IL12/shVEGF), demonstrating that oncolytic Ad-mediated elevation of antitumor cytokines was highly localized to tumor tissue. Here, IFNG is linked to neoplasm.