Efficient restoration of antitumor immunity in tumor tissue by treatment with RdB/IL12/shVEGF was further supported by the significantly higher IFN-γ/IL-6 cytokine ratio in tumor tissues treated with RdB/IL12/shVEGF than the other treatment groups, indicating efficient polarization of T cell responses toward the type 1 pattern and the establishment of a tumor microenvironment more favorable to the activation of tumor-specific immune cells (Figures 4A, 4B, and 4C). This evidence concerns the gene IL6 and neoplasm.