HMGA2 and neoplasm: As presented in Figure 6B as a plausible model, based on previous and current our findings, we can speculate that strong TRIM71 activity may suppress Lin28B-let-7-HMGA2 linked cellular transformation, since TRIM71 attenuates Lin28B function, thereby inhibiting growth of tumor cells via blockage of oncogenes such as HMGA2 as well as Myc and Ras targeted by let-7.