CRKL and acute lymphoblastic leukemia: At the same time, treatment for 4 h in ALL-SIL, PEER and BE-13 cells with 0.5 μM of BGT226, Torin-2, ZSTK474, and GSK690693 showed an almost complete shutdown of Ser473 Akt and S6 protein phosphorylation, while the phosphorylation status of CrkL was unchanged (Figure 3C).