BCR and acute lymphoblastic leukemia: To better assess the effects of the simultaneous in vitro treatment with BCR-ABL1 and PI3K/Akt/mTOR inhibitors, we examined by MTS assay the efficacy of Imatinib, Nilotinib and GZD824 in combination with BGT226, GSK690693, ZSTK474 and Torin-2 for 48 h in ALL-SIL and PEER cells.