Moreover, GZD824 strongly inhibited the proliferation of human leukemia cells harboring BCR-ABL1, including K562 and KU-812 CML cell lines as well as SUP-B15 B-ALL cells, with IC50 values in the nanomolar range [14]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.