Although we have shown here that TWEAK:Fn14 engagement in murine or human melanoma cells reduces invasive capacity, other studies have reported that TWEAK exhibits pro-invasive activity when added to certain human cancer cell lines; specifically, BT116 glioblastoma cells [11], HO-8910PM ovarian cancer cells [35] and both PC-3 and DU145 prostate cancer cells [39]. This evidence concerns the gene TNFRSF12A and cancer.