DLX5 and split hand-foot malformation: To scrutinize validity of the SSIS mechanism, here, we chose specifically to focus on the aetiology of t(7q11.21;9p12) translocation associated with SHFM in which the breakpoint in the centromere-proximal side is located over 41 million bases away from the DLX5 gene (figure 3) [47,48].